Glassy carbon microneedles-new transdermal drug delivery device derived from a scalable C-MEMS process.

ABSTRACT: Because carbon is the basic element of all life forms and has been successfully applied as a material for medical applications, it is desirable to investigate carbon for drug delivery applications, as well. In this work, we report the fabrication of a hollow carbon microneedle array with flow channels using a conventional carbon-microelectromechanical system (C-MEMS) process. This process utilizes the scalable and irreversible step of pyrolysis, where prepatterned SU-8 microneedles (precursor) are converted to glassy carbon structures in an inert atmosphere at high temperature (900 °C) while retaining their original shape upon shrinkage. Once converted to glassy carbon, the microneedles inherit the unique properties of hardness, biocompatibility, and thermal and chemical resistance associa

SUBMITTER: Mishra R 

PROVIDER: S-EPMC6295442 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature