Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale.

ABSTRACT: In cardiac cells, calcium is the mediator of excitation-contraction coupling. Dysfunctions in calcium handling have been identified as the origin of some cardiac arrhythmias. In the particular case of atrial myocytes, recent available experimental data has found links between these dysfunctions and structural changes in the calcium handling machinery (ryanodine cluster size and distribution, t-tubular network, etc). To address this issue, we have developed a computational model of an atrial myocyte that takes into account the detailed intracellular structure. The homogenized macroscopic behavior is described with a two-concentration field model, using effective diffusion coefficients of calcium in the sarcoplasmic reticulum (SR) and in the cytoplasm. The model reproduces the right calcium

SUBMITTER: Marchena M 

PROVIDER: S-EPMC6295473 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature