Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan.

ABSTRACT: Habitual aerobic exercise enhances physiological function and reduces risk of morbidity and mortality throughout life, but the underlying molecular mechanisms are largely unknown. The circulating proteome reflects the intricate network of physiological processes maintaining homeostasis and may provide insight into the molecular transducers of the health benefits of physical activity. In this exploratory study, we assessed the plasma proteome (SOMAscan proteomic assay; 1,129 proteins) of healthy sedentary or aerobic exercise-trained young women and young and older men ( n = 47). Using weighted correlation network analysis to identify clusters of highly co-expressed proteins, we characterized 10 distinct plasma proteomic modules (patterns). In healthy young (24 ± 1 yr) men and women, 4 modul

SUBMITTER: Santos-Parker JR 

PROVIDER: S-EPMC6295489 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature