Alterations of Graphic Properties and Related Cognitive Functioning Changes in Mild Alzheimer's Disease Revealed by Individual Morphological Brain Network.

ABSTRACT: Alzheimer's disease (AD) is one of the most common forms of dementia that has slowly negative impacts on memory and cognition. With the assistance of multimodal brain networks and graph-based analysis approaches, AD-related network disruptions support the hypothesis that AD can be identified as a dysconnectivity syndrome. However, as the recent emerging of individual-based morphological network research of AD, the utilization of multiple morphometric features may provide a broader horizon for locating the lesions. Therefore, the present study applied the newly proposed individual morphological brain network with five commonly used morphometric features (cortical thickness, regional volume, surface area, mean curvature, and fold index) to explore the topological aberrations and their relati

SUBMITTER: Li W 

PROVIDER: S-EPMC6295573 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature