Urinary Proteomics in Biomarker Discovery of Kidney-Related Disorders: Diabetic Nephropathy and Drug-Induced Nephrotoxicity in Chronic Headache.

ABSTRACT:

Objective

Urinary proteomics is primarily applied to the study of renal and urogenital tract disorders. Here are reported two distinct successful examples of this approach for the discovery of early urinary biomarkers of kidney-related dysfunctions: diabetic nephropathy (DN), a well-known complication of diabetes frequently leading to dialysis, and drug-induced nephrotoxicity, a possible condition caused by medication-overuse headache (MOH). Early detection of kidney disorders based on selective biomarkers could permit to diagnose patients at the initial stage of the disease, where the therapy may be suspended or prevent disease advancement.

Methods

Urine samples were first concentrated and desalted. Subsequently, they were subjected to two-dimensional gel electrophoresis (2

SUBMITTER: Bellei E 

PROVIDER: S-EPMC6295592 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature