A multi-layered nerve guidance conduit design adapted to facilitate surgical implantation.

ABSTRACT:

Background and aims

The gold standard procedure after a severe nerve injury is the nerve autograft, yet this technique has drawbacks. In recent years, progress has been made in the development of artificial nerve guides to replace the autograft, but no device has been able to demonstrate superiority. The present study introduces an adaptable foundation design for peripheral nerve regeneration.

Methods

Silk fibroin was electrospun, creating a tri-layered material with aligned fiber surfaces and a randomly deposited fiber interior. This material was rolled into a micro-channeled conduit, which was then enveloped by a jacket layer of the same tri-layered material.

Results

The proposed implant design succeeds in incorporating various desirable aspects of synthetic nerve g

SUBMITTER: Belanger K 

PROVIDER: S-EPMC6295612 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature