Associations of sperm mitochondrial DNA copy number and deletion rate with fertilization and embryo development in a clinical setting.

ABSTRACT:

Study question

Are sperm mitochondrial DNA copy number (mtDNAcn) and deletion rate (mtDNAdel) associated with odds of fertilization and high embryo quality at Days 3 and 5?

Summary answer

Higher sperm mtDNAcn and mtDNAdel were associated with lower odds of high quality Day 3 embryos and transfer quality Day 5 embryos, both of which were primarily driven by lowered odds of fertilization.

What is known already

Sperm mtDNAcn and mtDNAdel have been previously associated with poor semen parameters and clinical male infertility. One prior study has shown that mtDNAdel is associated with lower fertilization rates. However, it is unknown whether these characteristics are linked with ART outcomes.

Study design, size, duration

This prospective observational study include

SUBMITTER: Wu H 

PROVIDER: S-EPMC6295960 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature