Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

ABSTRACT:

Background & aims

Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and whether increases in the expression of muscle mRNAs and proteins reflecting increased muscle inflammation, atrophy and impaired carbohydrate oxidation were evident at the time of surgery, and both local and distant to the site of trauma, and could be associated with impaired glucoregulation.

Methods

Fifteen adult patients without diabetes undergoing major abdominal surgery participated in this observational study set in a university teaching hospital. Arterialised-venous blood samples and muscle biopsies were obtained before and after major e

SUBMITTER: Varadhan KK 

PROVIDER: S-EPMC6295976 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature