Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka.

ABSTRACT:

Background

Antibodies against the merozoite surface protein 1_-19 (MSP1_-19) and the apical membrane antigen 1 (AMA1) of the malaria parasite (Plasmodium vivax) are proven to be important in protection against clinical disease. Differences in the production/maintenance of antibodies may be due to many factors including host genetics. This paper discusses the association of 4 anti-malarial antibodies with selected host genetic markers.

Methods

Blood was collected from individuals (n = 242) with a history of malaria within past 15 years for DNA and serum. ELISA was carried out for serum to determine the concentration of anti-malarial antibodies MSP1_-19 and AMA1 for both vivax and falciparum malaria. 170 SNPs related to malaria were genotyped. Ass

SUBMITTER: Dewasurendra RL 

PROVIDER: S-EPMC6296029 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature