The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.

ABSTRACT:

Background

Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differentiation. However, cancer cells are trapped in a "pseudo-differentiated" state as they fail to expand mtDNA copy number. Global DNA methylation can regulate this process, as induced DNA demethylation promotes differentiation of cancer cells and expansion of mtDNA copy number.

Results

To determine the role that mtDNA methylation plays in regulating mtDNA replication during tumorigenesis, we have characterized the patterns of mtDNA methylation using glioblastoma and osteosarcoma tumor models that have different combinations of mtDNA genotypes

SUBMITTER: Sun X 

PROVIDER: S-EPMC6296150 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature