Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC6296170 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20181113 12
We report herein the design and synthesis of a series of orally active, liver-targeted hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors for the treatment of anemia. In order to mitigate the concerns for potential systemic side effects, we pursued liver-targeted HIF-PHD inhibitors relying on uptake via organic anion transporting polypeptides (OATPs). Starting from a systemic HIF-PHD inhibitor (<b>1</b>), medicinal chemistry efforts directed toward reducing permeability and, at the ...[more]