Heterogeneity in the respiratory symptoms of patients with mild-to-moderate COPD.

ABSTRACT:

Background

The burden of symptoms varies markedly between patients with COPD and is only weakly correlated with lung function impairment. While heterogeneity in lung function decline and exacerbations have been previously studied, the extent of heterogeneity in symptoms and the factors associated with this heterogeneity are not well understood.

Methods

A sample of the general Canadian population ≥40 years with persistent airflow limitation was followed for up to 3 years. Participants reported whether they experienced chronic coughing, phlegm, wheezing, or dyspnea during visits at 18-month intervals. We used mixed-effect logistic regression models (separately for each symptom) to assess overall heterogeneity in the occurrence of symptoms between individuals, and the proportio

SUBMITTER: Johnson KM 

PROVIDER: S-EPMC6296193 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature