Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses.

ABSTRACT:

Background/objective

Midkine (MDK) and pleiotrophin (PTN) are two closely related heparin-binding growth factors which are overexpressed in a wide variety of human cancers. We hypothesized that the concentrations of these factors in washout of biopsy needles would be higher in breast and lung cancer than in benign lesions.

Methods

Seventy subjects underwent pre-operative core needle biopsies of 78 breast masses (16 malignancies). In 11 subjects, fine needle aspiration was performed ex vivo on 7 non-small cell lung cancers and 11 normal lung specimens within surgically excised lung tissue. The biopsy needle was washed with buffer for immunoassay.

Results

The MDK/DNA and the PTN/DNA ratio in most of the malignant breast masses were similar to the ratios in benign masses

SUBMITTER: Giamanco NM 

PROVIDER: S-EPMC6296221 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature