Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres.

ABSTRACT: Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have the potential to better model human physiology with applications in toxicology, disease modeling, and the study of host-pathogen interactions. Several models of the human brain have been developed recently, demonstrating cell-cell interactions of multiple cell types with physiologically relevant 3D structures. Most current models, however, lack the ability to represent the inflammatory response in the brain because they do not include a microglial cell population. Microglia, the resident immunocompetent phagocytes in the central nervous system (CNS), are not only important in the inflammatory response and pathogenesis; they also function in normal brain development, strengthen neuronal conne

SUBMITTER: Abreu CM 

PROVIDER: S-EPMC6296317 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature