The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer.

ABSTRACT: Purpose: The most significant prognostic factor in early breast cancer is lymph node involvement. This stage between localized and systemic disease is key to understanding breast cancer progression; however, our knowledge of the evolution of lymph node malignant invasion remains limited, as most currently available data are derived from primary tumors.Experimental Design: In 11 patients with treatment-naïve node-positive early breast cancer without clinical evidence of distant metastasis, we investigated lymph node evolution using spatial multiregion sequencing (n = 78 samples) of primary and lymph node deposits and genomic profiling of matched longitudinal circulating tumor DNA (ctDNA).Results: Linear evolution from primary to lymph node was rare (1/11), wherea

SUBMITTER: Barry P 

PROVIDER: S-EPMC6296441 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature