Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor.

ABSTRACT: Peripheral Foxp3⁺ regulatory T cells (pT_regs) maintain immune homeostasis by controlling potentially harmful effector T cell responses toward dietary and microbial antigens. Although the identity of the T cell receptor (TCR) can impose commitment and functional specialization of T cells, less is known about how TCR identity governs pT_reg development from conventional CD4⁺ T cells. To investigate the extent to which TCR identity dictates pT_reg fate, we used somatic cell nuclear transfer to generate a transnuclear (TN) mouse carrying a monoclonal TCR from a pT_reg (pT_reg TN mice). We found that the pT_reg TCR did not inevitably predispose T cells to become pT_reg but instead allowed for differenti

SUBMITTER: Bilate AM 

PROVIDER: S-EPMC6296461 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature