Probing the Interplay between Amorphous Solid Dispersion Stability and Polymer Functionality.

ABSTRACT: Amorphous solid dispersions containing a polymeric component often impart improved stability against crystallization for a small molecule relative to the pure amorphous form. However, the relationship between side chain functionalities on a polymer and the ability of a polymer to stabilize against crystallization is not well understood. To shed light on this relationship, a series of polymers were functionalized from a parent batch of poly(chloromethylstyrene- co-styrene) to investigate the effect of functionality on the stability in amorphous solid dispersions without altering the physical parameters of polymers, such as the average molecular weight or backbone chain chemistry. The kinetics of the crystallization of the nonsteroidal anti-inflammatory drug nabumetone from amorphous solid d

SUBMITTER: Frank DS 

PROVIDER: S-EPMC6296464 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature