Modeling time-varying effects of multilevel risk factors of hospitalizations in patients on dialysis.

ABSTRACT: For chronic dialysis patients, a unique population requiring continuous medical care, methodologies to monitor patient outcomes, such as hospitalizations, over time, after initiation of dialysis, are of particular interest. Contributing to patient hospitalizations is a number of multilevel covariates such as demographics and comorbidities at the patient level and staffing composition at the dialysis facility level. We propose a varying coefficient model for multilevel risk factors (VCM-MR) to study the time-varying effects of covariates on patient hospitalization risk as a function of time on dialysis. The proposed VCM-MR also includes subject-specific random effects to account for within-subject correlation and dialysis facility-specific fixed effect varying coefficient functions to allow

SUBMITTER: Li Y 

PROVIDER: S-EPMC6296494 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature