Indomethacin blocks the increased conditioned rewarding effects of cocaine induced by repeated social defeat.

ABSTRACT: It is well established that repeated social defeat stress can induce negative long-term consequences such as increased anxiety-like behavior and enhances the reinforcing effect of psychostimulants in rodents. In the current study, we evaluated how the immune system may play a role in these long-term effects of stress. A total of 148 OF1 mice were divided into different experimental groups according to stress condition (exploration or social defeat) and pre-treatment (saline, 5 or 10 mg/kg of the anti-inflammatory indomethacin) before each social defeat or exploration episode. Three weeks after the last social defeat, anxiety was evaluated using an elevated plus maze paradigm. After this test, conditioned place preference (CPP) was induced by a subthreshold dose of cocaine (1 mg/kg). Biolog

SUBMITTER: Ferrer-Perez C 

PROVIDER: S-EPMC6296503 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature