Incidence trends and risk prediction nomogram of metachronous second primary lung cancer in lung cancer survivors.

ABSTRACT:

Background

This study was designed to estimate the trends in 5-year incidence of metachronous second primary lung cancer(SPLC) and to establish a risk prediction model to identify candidates who were at high risk of developing metachronous SPLC.

Methods

Incidence data between 2004 and 2007 were obtained from SEER database, including 42453 participants who survived ≥ 2 years after the initial diagnosis of lung cancer. Joinpoint regression analysis was used to calculate the 5-year incidence rates of metachronous SPLC per 100 000 population. Related risk factors of the survivors who developed MSPLC during five years were identified through logistic regression analysis, followed by establishment of risk prediction nomogram. Discrimination (C-index), calibration and decision anal

SUBMITTER: Hu ZG 

PROVIDER: S-EPMC6296553 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature