HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer.

ABSTRACT:

Background

Aberrant activation of the signal transducer and activator of transcription 3 (STAT3) is frequently seen in patients with gastric cancer (GC), and is generally associated with worse prognosis. HJC0152, a novel STAT3 inhibitor, has shown significant anti-tumor effects in several cancers, although its role in GC remains to be clarified.

Methods

The effect of HJC0152 on STAT3 signaling pathway and the biological behaviors of GC cells were evaluated through in vitro and/or in vivo experiments. Meanwhile, RNA sequence analysis was used to further explore its potential anti-tumor mechanisms.

Results

HJC0152 inhibited the expression of activated STAT3 and its downstream target genes (c-Myc and clyclinD1) in GC cells, and restrained tumor growth in vivo. HJC0152 tr

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6296682 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature