Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles.

ABSTRACT:

Purpose

This study proposes the utilization of multispectral optoacoustic tomography (MSOT) to investigate the intratumoral distribution of polymeric micelles and effect of size on the biodistribution and antitumor efficacy (ATE).

Materials and methods

Docetaxel and/or optoacoustic agent-loaded polymeric micelles (with diameters of 22, 48, and 124 nm) were prepared using amphiphilic block copolymers poly (ethylene glycol) methyl ether-block-poly (D,L lactide) (PEG₂₀₀₀-PDLLA_x). Subcutaneous 4T1 tumor-bearing mice were monitored with MSOT imaging and IVIS^® Spectrum in vivo live imaging after tail vein injection of micelles. The in vivo results and ex vivo confocal imaging results were then compared. Next, ATE of the three micelles was found and

SUBMITTER: Cong Z 

PROVIDER: S-EPMC6296692 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature