Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.

ABSTRACT: Nickel is a component of several alloy types that are widely used in our environment, including several dental alloy types that cause intraoral metal contact allergy. However, metal-specific immune responses in the oral mucosa have not been elucidated because a suitable animal model has not been established. In this study, we established a novel murine model of nickel-induced intraoral metal contact allergy and aimed to elucidate the immune response in terms of T-cell receptor repertoire and cytokine profiles in inflamed oral mucosa. The intraoral metal contact allergy model was induced by two sensitizations of nickel plus lipopolysaccharide solution into the postauricular skin followed by a single nickel challenge of the buccal mucosa. Cytokine expression profiles and T-cell phenotypes we

SUBMITTER: Nakasone Y 

PROVIDER: S-EPMC6296741 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature