Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents.

ABSTRACT: The cell plasma membrane serves as a nexus integrating extra- and intracellular components, which together enable many of the fundamental cellular signaling processes that sustain life. In order to perform this key function, plasma membrane components assemble into well-defined domains exhibiting distinct biochemical and biophysical properties that modulate various signaling events. Dysregulation of these highly dynamic membrane domains can promote oncogenic signaling. Recently, it has been demonstrated that select membrane-targeted dietary bioactives (MTDBs) have the ability to remodel plasma membrane domains and subsequently reduce cancer risk. In this review, we focus on the importance of plasma membrane domain structural and signaling functionalities as well as how loss of membrane hom

SUBMITTER: Erazo-Oliveras A 

PROVIDER: S-EPMC6296755 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature