Statins associate with improved mortality among patients with certain histological subtypes of lung cancer.

ABSTRACT:

Objectives

To measure the association between statin exposure and mortality in lung cancer patients belonging to different categories of histological subtype.

Materials and methods

A cohort of 19,974 individuals with incident lung cancer between 2007 and 2011 was identified using the SEER-Medicare linked database. Statin exposure both pre- and post-diagnosis was analyzed to identify a possible association with cancer-specific mortality in patients stratified by histological subtype. Intention-to-treat analyses and time-dependent Cox regression models were used to calculate hazard ratios and 95% confidence intervals (95% CIs) corresponding to statin exposure both pre- and post-diagnosis, respectively.

Results

Overall baseline statin exposure was associated with a decre

SUBMITTER: Ung MH 

PROVIDER: S-EPMC6296763 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature