The human gut microbiome in early-onset type 1 diabetes from the TEDDY study.

ABSTRACT: Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic and environmental factors¹, including complex genetic elements², patient exposures³ and the gut microbiome⁴. Viral infections⁵ and broader gut dysbioses⁶ have been identified as potential causes or contributing factors; however, human studies have not yet identified microbial compositional or functional triggers that are predictive of islet autoimmunity or T1D. Here we analyse 10,913 metagenomes in stool samples from 783 mostly white, non-Hispanic children. The samples were collected monthly from three months of age until the clinical end point (islet autoimmunity or T1D) in the The Environmental Determinants of D

SUBMITTER: Vatanen T 

PROVIDER: S-EPMC6296767 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature