Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study.

ABSTRACT: Longitudinal studies have shown that clinical precursors of antisocial personality disorder (ASPD) include attention-deficit/hyperactivity disorder (ADHD) and more notably comorbid ADHD and conduct disorder (CD). Despite existing evidence for the purported role of abnormal serotonergic function in aggressive youth and adults, little evidence exists on the role of serotonin in the progression from childhood disruptive behavior disorders to adult psychopathology, including ASPD. This study examined the relation between serotonergic function in children diagnosed with ADHD and the development of ASPD in early adulthood. We hypothesized that low serotonin response to a pharmacological probe in childhood would predict the development of adult ASPD. Towards this goal we divided 40 adults (M = 37

SUBMITTER: Ivanov I 

PROVIDER: S-EPMC6296770 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature