Quantitative susceptibility mapping (QSM) with an extended physical model for MRI frequency contrast in the brain: a proof-of-concept of quantitative susceptibility and residual (QUASAR) mapping.

ABSTRACT: Quantitative susceptibility mapping (QSM) aims to calculate the tissue's magnetic susceptibility distribution from its perturbing effect on the MRI static main magnetic field. The method is increasingly being applied to study iron and myelin in clinical and preclinical settings. However, recent experimental and theoretical findings have challenged the fundamental theoretical assumptions that form the basis of current numerical implementations of QSM algorithms. The present work introduces a new class of susceptibility mapping algorithms, termed quantitative susceptibility and residual mapping (QUASAR), which takes into account frequency contributions not related to the spatial variation of bulk magnetic susceptibility in the Lorentz sphere model. We present a simple proof-of-concept QUASAR

SUBMITTER: Schweser F 

PROVIDER: S-EPMC6296773 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature