Retinal ganglion cell-inner plexiform layer thickness is nonlinearly associated with cognitive impairment in the community-dwelling elderly.

ABSTRACT:

Introduction

Thinning of optical coherence tomography-measured retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear.

Methods

This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition.

Results

The performance of global cognition decreased as mean GC-IPL of bilateral eyes deviated from the sample mean (77.5 μm) (quadratic GC-IPL: β = -0.49 × 10^-2; 95% confidence interval: -0.74 × 10

SUBMITTER: Liu YL 

PROVIDER: S-EPMC6297049 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature