Quantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements.

ABSTRACT: Photoacoustic imaging (PAI) provides information on haemoglobin levels and blood oxygenation (sO₂). To facilitate assessment of the variability in sO₂ and haemoglobin in tumours, for example in response to therapies, the baseline variability of these parameters was evaluated in subcutaneous head and neck tumours in mice, using a PAI system (MSOTinVision-256TF). Tumours of anaesthetized animals (midazolam-fentanyl-medetomidine) were imaged for 75 min, in varying positions, and repeatedly over 6 days. An increasing linear trend for average tumoural haemoglobin and blood sO₂ was observed, when imaging over 75 min. There were no significant differences in these temporal trends, when repositioning tumours. A negative correlation was found between the percent dec

SUBMITTER: Martinho Costa M 

PROVIDER: S-EPMC6297191 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature