Potential functions of long non‑coding RNAs in the osteogenic differentiation of human bone marrow mesenchymal stem cells.

ABSTRACT: Long non‑coding RNAs (lncRNAs) are a specific group of RNA molecules that do not encode proteins. They have been shown to serve important regulatory functions in various biological and cell differentiation processes. However, the potential functions and regulatory mechanisms of lncRNAs that are associated with the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) remain to be elucidated. The present study aimed to investigate lncRNAs that are differentially expressed during the osteogenic differentiation of hBMSCs, along with the potential functions of those lncRNAs. To this end, three groups of hBMSCs were stimulated to undergo osteogenic differentiation for 7 days. Known lncRNAs, unknown lncRNAs and mRNAs that demonstrated differential expression prior to an

SUBMITTER: Sun X 

PROVIDER: S-EPMC6297760 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature