Network Representation of T-Cell Repertoire- A Novel Tool to Analyze Immune Response to Cancer Formation.

ABSTRACT: The T cell repertoire potentially presents complexity compatible, or greater than, that of the human brain. T cell based immune response is involved with practically every part of human physiology, and high-throughput biology needed to follow the T-cell repertoire has made great leaps with the advent of massive parallel sequencing [1]. Nevertheless, tools to handle and observe the dynamics of this complexity have only recently started to emerge [e.g., 2, 3, 4] in parallel with sequencing technologies. Here, we present a network-based view of the dynamics of the T cell repertoire, during the course of mammary tumors development in a mouse model. The transition from the T cell receptor as a feature, to network-based clustering, followed by network-based temporal analyses, provides novel insi

SUBMITTER: Priel A 

PROVIDER: S-EPMC6297828 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature