Anticipation of Uncertain Threat Modulates Subsequent Affective Responses and Covariation Bias.

ABSTRACT: Uncertainty contributes to stress and anxiety-like behaviors by impairing the ability of participants to objectively estimate threat. Our study used the cue-picture paradigm in conjunction with the event-related potential (ERP) technique to explore the temporal dynamics of anticipation for and response to uncertain threat in healthy individuals. This task used two types of cue. While 'certain' cues precisely forecasted the valence of the subsequent pictures (negative or neutral), the valence of pictures following 'uncertain' cues was not predictable. ERP data showed that, during anticipation, uncertain cues elicited similar Stimulus-Preceding Negativity (SPN) to certain-negative cues, while both of them elicited larger SPN than certain-neutral cues. During affective processing, uncertainty

SUBMITTER: Qiao Z 

PROVIDER: S-EPMC6297831 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature