Butyrate Produced by Commensal Bacteria Down-Regulates <i>Indolamine 2,3-Dioxygenase 1</i> (<i>IDO-1</i>) Expression <i>via</i> a Dual Mechanism in Human Intestinal Epithelial Cells.

ABSTRACT: Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to the global well-being of their host. A wide variety of metabolites produced by commensal bacteria are influencing host health but the characterization of the multiple molecular mechanisms involved in host-microbiota interactions is still only partially unraveled. The intestinal epithelial cells (IECs) take a central part in the host-microbiota dialogue by inducing the first microbial-derived immune signals. Amongst the numerous effector molecules modulating the immune responses produced by IECs, indoleamine 2,3-dioxygenase-1 (IDO-1) is essential for gut homeostasis. IDO-1 expression is dependent on the microbiota and despites its central role, how the commensal bac

SUBMITTER: Martin-Gallausiaux C 

PROVIDER: S-EPMC6297836 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature