Impact of frequent apheresis blood donation on bone density: A prospective, longitudinal, randomized, controlled trial.

ABSTRACT:

Background

Blood for transfusion is lifesaving and essential to many elements of modern medical practice. The global blood supply relies on volunteer blood donors. Apheresis is increasingly used to collect blood and requires anticoagulant to prevent extracorporeal coagulation. Citrate, the standard apheresis anticoagulant, chelates ionized calcium with consequent perturbations of serum calcium, parathyroid hormone, vitamin D, and markers of bone remodeling in donors. Cross-sectional studies of bone mineral density (BMD) among apheresis donors exhibit conflicting results.

Methods

The longitudinal, randomized, controlled ALTRUYST trial (NCT02655055) was undertaken to determine whether BMD declined following high frequency apheresis blood donation over 1 year. The study was pow

SUBMITTER: Bialkowski W 

PROVIDER: S-EPMC6297840 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature