The Association Between β-Blocker Use and Cardiorespiratory Fitness: The Maastricht Study.

ABSTRACT:

Purpose

β-Blockers (BBs) have been associated with a reduced cardiorespiratory fitness (CRF). This is possibly caused by inhibition of β2-receptors in the airways. However, there are limited data available on β-receptor selectivity and CRF. We therefore aimed to assess the association between BB use and CRF and to assess the association between β-receptor selectivity and CRF.

Methods

Participants in the Maastricht Study were aged between 40 and 75 years. Exposure to BB use was determined by use of pharmacy records. General linear models were used to obtain adjusted means of 2 proxies for CRF: covered distance during the 6-minute walk test (6MWT) and estimated maximum power output adjusted for body mass ( W_max kg^-1) during the submaximal cycle ergometer

SUBMITTER: Nielen JTH 

PROVIDER: S-EPMC6297897 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature