Nucleus-enriched Ruthenium Polypyridine Complex Acts as a Potent Inhibitor to Suppress Triple-negative Breast Cancer Metastasis In vivo.

ABSTRACT: Polypyridine Ru(II) complexes have long been deemed to excellent antitumor agents that inhibit the proliferation of breast cancer cells. Nevertheless, their effects on the metastatic potency of breast cancer cells need further research. Herein, a class of polypyridine Ru(II) complexes coordinated with phenazine derivates (DPPZ) ([Ru(bpy)₂(DPPZ-R)](ClO₄)₂, Ru(bpy) ₂ DPPZ: R = -H, Ru(bpy) ₂ BrDPPZ: R = -Br, Ru(bpy) ₂ MDPPZ: R = -CH₃, Ru(bpy)2BnDPPZ: R = -acene, Ru(bpy) ₂ BEDPPZ: R = -C ≡ C(C₆H₅)) was synthesized by introducing different substituent groups to regulate the electron cloud density

SUBMITTER: Zhao X 

PROVIDER: S-EPMC6297906 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature