Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata.

ABSTRACT:

Background

Aconiti Lateralis Radix Praeparata has been used as the first cardiac drug over a 1000 years in Asian countries. Although most detoxification products are confirmed to be safe, the effect is not potent as desired. In previous study, we designed a one-step detoxification product by fresh cutting and continuously dried, which preserved more water-soluble alkaloids while eliminating toxicity. It is thus necessary to find more in vivo evidence to support its industrial development.

Methods

Initially, network pharmacology was applied to analyze the related pathways of candidate components acting on heart failure diseases. Then, two heart failure models that were induced by propafenone hydrochloride and nimodipine (v/v, 1:1) and were given doxorubicin were carrie

SUBMITTER: He YN 

PROVIDER: S-EPMC6297959 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature