Signatures within the esophageal microbiome are associated with host genetics, age, and disease.

ABSTRACT:

Background

The esophageal microbiome has been proposed to be involved in a range of diseases including the esophageal adenocarcinoma cascade; however, little is currently known about its function and relationship to the host. Here, the esophageal microbiomes of 106 prospectively recruited patients were assessed using 16S rRNA and 18S rRNA amplicon sequencing as well as shotgun sequencing, and associations with age, gender, proton pump inhibitor use, host genetics, and disease were tested.

Results

The esophageal microbiome was found to cluster into functionally distinct community types (esotypes) defined by the relative abundances of Streptococcus and Prevotella. While age was found to be a significant factor driving microbiome composition, bacterial signatures and functions

SUBMITTER: Deshpande NP 

PROVIDER: S-EPMC6297961 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature