Biomimetic recyclable microgels for on-demand generation of hydrogen peroxide and antipathogenic application.

ABSTRACT: Microgels that can generate antipathogenic levels of hydrogen peroxide (H₂O₂) through simple rehydration in solutions with physiological pH are described herein. H₂O₂ is a widely used disinfectant but the oxidant is hazardous to store and transport. Catechol, an adhesive moiety found in mussel adhesive proteins, was incorporated into microgels, which generated 1-5 mM of H₂O₂ for up to four days as catechol autoxidized. The sustained release of low concentrations of H₂O₂ was antimicrobial against both gram-positive (Staphylococcus epidermidis) and gram-negative (Escherichia coli) bacteria and antiviral against both non-enveloped porcine parvovirus (PPV) and enveloped bovine viral diarrhea virus (BVDV). T

SUBMITTER: Meng H 

PROVIDER: S-EPMC6298039 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature