SonicParanoid: fast, accurate and easy orthology inference.

ABSTRACT:

Motivation

Orthology inference constitutes a common base of many genome-based studies, as a pre-requisite for annotating new genomes, finding target genes for biotechnological applications and revealing the evolutionary history of life. Although its importance keeps rising with the ever-growing number of sequenced genomes, existing tools are computationally demanding and difficult to employ.

Results

Here, we present SonicParanoid, which is faster than, but comparably accurate to, the well-established tools with a balanced precision-recall trade-off. Furthermore, SonicParanoid substantially relieves the difficulties of orthology inference for those who need to construct and maintain their own genomic datasets.

Availability and implementation

SonicParanoid is available

SUBMITTER: Cosentino S 

PROVIDER: S-EPMC6298048 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature