Comparative assessment of different familial aggregation methods in the context of large and unstructured pedigrees.

ABSTRACT:

Motivation

Familial aggregation analysis is an important early step for characterizing the genetic determinants of phenotypes in epidemiological studies. To facilitate this analysis, a collection of methods to detect familial aggregation in large pedigrees has been made available recently. However, efficacy of these methods in real world scenarios remains largely unknown. Here, we assess the performance of five aggregation methods to identify individuals or groups of related individuals affected by a Mendelian trait within a large set of decoys. We investigate method performance under a representative set of combinations of causal variant penetrance, trait prevalence and number of affected generations in the pedigree. These methods are then applied to assess familial aggregation of

SUBMITTER: Weichenberger CX 

PROVIDER: S-EPMC6298062 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature