Insulin depot absorption modeling and pharmacokinetic simulation with insulin glargine 300 U/mL
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ABSTRACT:

Objective

Mathematical models of insulin absorption have been used to predict plasma insulin concentrations after administration, but few are specifically applicable to insulin glargine, which precipitates subcutaneously after injection.

Materials and methods

The formation and redissolution of subcutaneous depots of insulin glargine 100 U/mL (Gla-100) and insulin glargine 300 U/mL (Gla-300) are modeled. Surface-area-dependent redissolution is introduced to established diffusion and absorption pathways, and pharmacokinetic (PK) profiles are simulated and subsequently validated using experimental data from euglycemic glucose clamp studies. Simulations are used to predict the PK effect of adapting the timing of once-daily insulin injections and of switching from one insulin pro

SUBMITTER: Lindauer K 

PROVIDER: S-EPMC6298133 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature