Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the effectiveness and safety of dual agent antiplatelet therapy combining clopidogrel and aspirin to prevent recurrent thrombotic and bleeding events compared with aspirin alone in patients with acute minor ischaemic stroke or transient ischaemic attack (TIA).

Design

Systematic review and meta-analysis of randomised, placebo controlled trials.

Data sources

Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Library, ClinicalTrials.gov, WHO website, PsycINFO, and grey literature up to 4 July 2018.

Eligibility criteria for selecting studies and methods

Two reviewers independently screened potentially eligible studies according to predefined selection criteria and assessed the risk of bias using a modified version of the C

SUBMITTER: Hao Q 

PROVIDER: S-EPMC6298178 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature