Whole Blood Gene Expression Associated With Clinical Biological Age.

ABSTRACT:

Background

Biologic age may better reflect an individual's rate of aging than chronologic age.

Methods

We conducted a transcriptome-wide association study with biologic age estimated with clinical biomarkers, which included: systolic blood pressure, forced expiratory volume at 1 second (FEV1), total cholesterol, fasting glucose, C-reactive protein, and serum creatinine. We assessed the association between the difference between biologic age and chronologic age (∆age) and gene expression in whole blood measured using the Affymetrix Human Exon 1.0st Array.

Results

Our discovery sample included 2,163 participants from the Framingham Offspring cohort (mean age 67 ± 9 years, 55% women). A total of 481 genes were significantly associated with ∆age (p < 2.8 × 10-6). Among th

SUBMITTER: Lin H 

PROVIDER: S-EPMC6298179 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature