Association of Biomarker and Physiologic Indices With Mortality in Older Adults: Cardiovascular Health Study.

ABSTRACT:

Background

A goal of gerontology is discovering aging phenotypes that reflect biological aging distinct from disease pathogenesis. Biomarkers that strongly and independently associated with mortality and that statistically attenuated chronologic age could be used to define such a phenotype. We determined the association of a Biomarker Index (BI) with mortality and compared it with a validated Physiologic Index (PI) in older adults.

Methods

The indices were constructed in the Cardiovascular Health Study, mean (SD) age 74.5 (5.1) years. The BI incorporated circulating levels of new biomarkers, including insulin-like growth factor-1, insulin-like growth factor-binding protein 3, amino-terminal pro-B-type natriuretic peptide, dehydroepiandrosterone sulfate, and interleukin-6, an

SUBMITTER: Sanders JL 

PROVIDER: S-EPMC6298182 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature