Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

ABSTRACT:

Background

Centenarian offspring have better health and lower mortality in comparison to referent cohorts, however it is unknown whether they have preserved cognition at older ages.

Methods

This prospective study of 491 centenarian offspring and 270 referent participants without familial longevity (mean baseline age 75.5 years) from the New England Centenarian Study analyzed longitudinal cognitive assessments performed using the Telephone Interview for Cognitive Status. Logistic regression was used for cognitive impairment at baseline and Cox proportional hazards regression for risk of incident cognitive impairment.

Results

After adjustment for age, sex, education, stroke, and diabetes, offspring were 46% less likely to have baseline cognitive impairment (adjusted odd

SUBMITTER: Andersen SL 

PROVIDER: S-EPMC6298187 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature