A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies.

ABSTRACT: Background: Acute respiratory infections (ARIs) are the leading indication for antibacterial prescriptions despite a viral etiology in the majority of cases. The lack of available diagnostics to discriminate viral and bacterial etiologies contributes to this discordance. Recent efforts have focused on the host response as a source for novel diagnostic targets although none have explored the ability of host-derived microRNAs (miRNA) to discriminate between these etiologies. Methods: In this study, we compared host-derived miRNAs and mRNAs from human H3N2 influenza challenge subjects to those from patients with Streptococcus pneumoniae pneumonia. Sparse logistic regression models were used to generate miRNA signatures diagnostic of ARI etiologies. Generalized linear mode

SUBMITTER: Poore GD 

PROVIDER: S-EPMC6298190 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature