Investigating the impact of cigarette smoking behaviours on DNA methylation patterns in adolescence.

ABSTRACT: Smoking usually begins in adolescence, and early onset of smoking has been linked to increased risk of later life disease. There is a need to better understand the biological impact of cigarette smoking behaviours in adolescence. DNA methylation profiles related to smoking behaviours and cessation in adulthood have been previously identified, but alterations arising from smoking initiation have not been thoroughly investigated. We aimed to investigate DNA methylation in the Avon Longitudinal Study of Parents and Children in relation to (1) different smoking measures, (2) time since smoking initiation and frequency of smoke exposure and (3) latent classes of smoking behaviour. Using 2620 CpG sites previously associated with cigarette smoking, we investigated DNA methylation change in relati

SUBMITTER: Prince C 

PROVIDER: S-EPMC6298233 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature