Evaluating the Effect of Lymph Node Status on Survival in Large Colon Cancer.

ABSTRACT: Objective: This study aimed to investigate the effect of lymph node status on survival in large colon cancer. Methods: In the first cohort, patients diagnosed with non-metastatic colon cancer (N = 176,834) were identified from the Surveillance, Epidemiology, and End Results (SEER) database between January 1988 and December 2005. Further analyses were conducted in the other cohort (N = 855) from the Fudan University Shanghai Cancer Center (FUSCC) database. Results: In the SEER cohort, CSS differences increased as the tumor enlarged until a threshold tumor size group (tumor measuring 7-8 cm, P < 0.001) was reached, in which node positivity showed the maximum negative effect on CSS; multivariate Cox analyses showed that tumors measuring 7-8 cm present

SUBMITTER: Liu Q 

PROVIDER: S-EPMC6298250 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature